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Chemical transdifferentiation: closer to regenerative medicine

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《医学前沿（英文）》 2016年第10卷第2期页码 152-165 doi: 10.1007/s11684-016-0445-z

摘要：

Cell transdifferentiation, which directly switches one type of differentiated cells into another cell type, is more advantageous than cell reprogramming to generate pluripotent cells and differentiate them into functional cells. This process is crucial in regenerative medicine. However, the cell-converting strategies, which mainly depend on the virus-mediated expression of exogenous genes, have clinical safety concerns. Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversion. In this review, we briefly retrospect the nature of cell transdifferentiation and summarize the current developments in the research of small molecules in promoting cell conversion. Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which is closer to the clinical translation in cell therapy. Despite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely unknown. More importantly, identifying drugs that induce resident cell conversion in vivo to repair damaged tissue remains to be the end-goal in current regenerative medicine.

关键词： cell therapy cell transdifferentiation chemical compounds small molecules tissue regeneration

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Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

《医学前沿（英文）》 2011年第5卷第4期页码 372-378 doi: 10.1007/s11684-011-0164-4

摘要： Regenerative medicine is an emerging interdisciplinary field of research that uses several technological approaches including stem cells to repair tissues. Mesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest over the past decade in this field. Numerous studies have explored the role of MSCs in tissue repair and modulation of allogeneic immune responses. The mechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cells as follows: the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial, and neuronal cells; the ability to secrete multiple bioactive molecules capable of stimulating the recovery of injured cells and inhibiting inflammation; the lack of immunogenicity; and the ability to perform immunomodulatory functions. In the present review, we focus on these three aspects upon which the therapeutic effects of MSCs are mainly based. Furthermore, some pathological conditions under which the application of MSCs should be done with caution are also mentioned.

关键词： mesenchymal stem cells differentiation immunomodulation regenerative medicine

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Evaluation of regenerative braking based on single-pedal control for electric vehicles

Wei LIU, Xintian LIU, Yansong WANG, Hongzhong QI

《机械工程前沿（英文）》 2020年第15卷第1期页码 166-179 doi: 10.1007/s11465-019-0546-x

摘要： More than 25% of vehicle kinetic energy can be recycled under urban driving cycles. A single-pedal control strategy for regenerative braking is proposed to further enhance energy efficiency. Acceleration and deceleration are controlled by a single pedal, which alleviates driving intensity and prompts energy recovery. Regenerative braking is theoretically analyzed based on the construction of the single-pedal system, vehicle braking dynamics, and energy conservation law. The single-pedal control strategy is developed by considering daily driving conditions, and a single-pedal simulation model is established. Typical driving cycles are simulated to verify the effectiveness of the single-pedal control strategy. A dynamometer test is conducted to confirm the validity of the simulation model. Results show that using the single-pedal control strategy for electric vehicles can effectively improve the energy recovery rate and extend the driving range under the premise of ensuring safety while braking. The study lays a technical foundation for the optimization of regenerative braking systems and development of single-pedal control systems, which are conducive to the promotion and popularization of electric vehicles.

关键词： electric vehicle single-pedal control regenerative braking co-simulation dynamometer test

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Regenerative braking control strategy in mild hybrid electric vehicles equipped with automatic manual

QIN Datong, YE Ming, LIU Zhenjun

《机械工程前沿（英文）》 2007年第2卷第3期页码 364-369 doi: 10.1007/s11465-007-0064-0

摘要： The actual regenerative braking force of an integrated starter/generator (ISG), which is varied with desired braking deceleration and vehicle speed, is calculated based on an analysis of the required deceleration, maximum braking force of ISG, engine braking force and state of charge (SOC) of battery. Braking force distribution strategies are presented according to the actual regenerative braking force of ISG. To recover the vehicle s kinetic energy maximally, braking shift rules for a mild hybrid electric vehicle (HEV) equipped with automatic manual transmission (AMT) are brought forward and effects of transmission ratios are considered. A test-bed is built up and regenerative braking tests are carried out. The results show that power recovered by the braking shift rules is more than that recovered by the normal braking control rules.

关键词： SOC Braking battery regenerative braking starter/generator

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Developing a new agenda for increased food and climate security

《农业科学与工程前沿（英文）》 doi: 10.15302/J-FASE-2023514

摘要：

● The urgent need to address increasing worldwide food and climate insecurity.

关键词： climate resilience food security human health planetary health regenerative agriculture

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Soil security and global food security

《农业科学与工程前沿（英文）》 doi: 10.15302/J-FASE-2023530

摘要：

● Much of the world’s agricultural land has been degraded through soil loss and degradation of soil organic matter.

关键词： Agriculture soil security food security regenerative

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Therapeutic potential of stem cell in liver regeneration

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《医学前沿（英文）》 2011年第5卷第1期页码 26-32 doi: 10.1007/s11684-011-0107-0

摘要：

Liver transplantation is the only life-saving procedure for patients with end-stage liver disease. However, its potential benefits are hampered by many disadvantages, such as the relative shortage of donors, operative risks, and high costs. These issues have prompted the search for new alternative therapies for irreversible liver disease. Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation, is a promising alternative approach. Several studies have demonstrated that transplantation of hepatic stem/progenitor cells or hepatocyte-like cells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver and improved survival rates in experimental models of liver disease. However, a registered clinical application based on stem cell technology will take at least an additional 5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratoma formation. This review summarizes the general understanding of the therapeutic potentials of stem cells in liver disease, including the sources, mechanisms, and delivery methods of hepatic stem cells in liver regeneration, and discusses some challenges for their therapeutic application.

关键词： stem cell liver disease regenerative medicine

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Microorganism-derived biological macromolecules for tissue engineering

《医学前沿（英文）》 2022年第16卷第3期页码 358-377 doi: 10.1007/s11684-021-0903-0

摘要： According to literature, certain microorganism productions mediate biological effects. However, their beneficial characteristics remain unclear. Nowadays, scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative medicine. The present review aims to introduce microorganism-derived biological macromolecules, such as pullulan, alginate, dextran, curdlan, and hyaluronic acid, and their available sources for tissue engineering. Growing evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological applications. These natural-based materials are attractive in pharmaceutical, regenerative medicine, and biomedical applications. This study provides a detailed overview of natural-based biomaterials, their chemical and physical properties, and new directions for future research and therapeutic applications.

关键词： biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate

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Energy-saving operation approaches for urban rail transit systems

Ziyou GAO, Lixing YANG

《工程管理前沿（英文）》 2019年第6卷第2期页码 139-151 doi: 10.1007/s42524-019-0030-7

摘要： With the accelerated urbanization in China, passenger demand has dramatically increased in large cities, and traffic congestion has become serious in recent years. Developing public urban rail transit systems is an indispensable approach to overcome these problems. However, the high energy consumption of daily operations is an emerging issue due to increased rail transit networks and passenger demands. Thus, reducing the energy consumption and operational cost by using advanced optimization methodologies is an urgent task for operation managers. This work systematically introduces energy-saving approaches for urban rail transit systems in three aspects, namely, train speed profile optimization, utilization of regenerative energy, and integrated optimization of train timetable and speed profile. Future research directions in this field are also proposed to meet increasing passenger demands and network-based urban rail transit systems.

关键词： urban rail transit energy saving speed profile optimization regenerative energy train timetable

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我国细胞技术类再生医学创新型技术产业发展战略研究

卢世璧,吴祖泽,付小兵,郭全义,程瑾,赵师充,郭维民

《中国工程科学》 2017年第19卷第2期页码 95-99 doi: 10.15302/J-SSCAE-2017.02.016

摘要：

近十年来国内外再生医学创新型医疗技术产业显示出了巨大的潜力和发展前景。本文通过查阅、整理和分析美国、欧盟成员国、日本、澳大利亚等典型发达国家在细胞技术类再生医学创新型医疗技术产业的现状和相关的政策法规、管理机制及其面临的问题，研究了我国在该技术产业的发展现状和政府的监管政策及管理机制，分析和总结了该产业的发展趋势、特点和存在的问题，提出以大力发展我国细胞技术类再生医学创新型医疗技术产业为原则，以突破产业发展的瓶颈为出发点的系列专家建议和意见。

关键词：再生医学干细胞产业发展

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Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

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《医学前沿（英文）》 2018年第12卷第2期页码 139-152 doi: 10.1007/s11684-017-0551-6

摘要：

Current research on common musculoskeletal problems, including osteoarticular conditions, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients’ outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rich plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure.

关键词： regenerative medicine joint conditions muscle injuries platelet rich plasma tendinopathy healing mechanisms

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膝关节骨性关节炎治疗的再生工程：生物材料以及基于细胞的技术

Jorge L. Escobar Ivirico, Maumita Bhattacharjee, Emmanuel Kuyinu, Lakshmi S. Nair, Cato T. Laurencin

《工程（英文）》 2017年第3卷第1期页码 16-27 doi: 10.1016/J.ENG.2017.01.003

摘要：

膝关节骨性关节炎(OA) 是世界上常见的关节炎，其发病率年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA 治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA 的方法虽取得了一定疗效，但仍没有种方法可达到全膝关节置换术(TKA) 的治疗效果TKA 主要应用于治疗末期膝关节OA，其缺点是有手术侵入性和手术费用昂贵。因而，应该重视创新性的再生术，以推迟甚至消除患者对TKA 的需求一些基于生物材料和细胞的疗法目前正处于发展阶段，并已在临床前和临床研究方面取得了初步进展单独或联合应用先进的生物材料和干细胞治疗膝关节OA 可减轻疼痛，使损害的关节软骨再生。在此综述中，我们讨论了膝关节OA 疼痛和软骨损害的发病机制，并探讨了该病的新治疗策略及其局限

关键词：膝关节骨性关节炎骨关节炎疼痛间充质干细胞生物材料再生工程